Nigerian hopefuls Rivers United will face title-holders Pyramids of Egypt after the CAF Champions League group draw was made in Johannesburg on Monday.
Renaissance Berkane of Morocco and Power Dynamos of Zambia complete Group A, with Pyramids the only club among the four that have qualified before for the mini-league phase.
Although Nigeria rank among the powerhouses of African football, only one club from the most populous country on the continent, Enyimba, have won the competition.
After Enyimba won back-to-back titles in 2003 and 2004, no Nigerian club has come close to repeating the feat.
Rivers had a tough passage to the group draw, shading Aigles of the Democratic Republic of Congo and Black Bulls of Mozambique with one-goal aggregate victories.